Significance of hyposmia in isolated REM sleep behavior disorder
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ORIGINAL COMMUNICATION
Significance of hyposmia in isolated REM sleep behavior disorder Alex Iranzo1 · Paula Marrero‑González1 · Mónica Serradell1 · Carles Gaig1 · Joan Santamaria1 · Isabel Vilaseca2 Received: 13 July 2020 / Revised: 11 September 2020 / Accepted: 14 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objective To determine if hyposmia in isolated REM sleep behavior disorder (IRBD) predicts short-term conversion to any α-synucleinopathy and declines with time. Methods Olfaction was tested using the University of Pennsylvania Smell Identification Test (UPSIT-40) in 140 consecutive patients with polysomnography-confirmed IRBD and in 77 matched controls. Patients were followed-up during 5.6 ± 3.9 (range 0.2–13) years. Twenty-one patients underwent serial UPSIT-40 evaluations at 1–3 and 4–6 years after baseline. Results UPSIT-40 score was lower in patients than in controls (20.2 ± 6.5 vs. 28.6 ± 5.0; p
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