Small Animal Imaging Basics and Practical Guide
Small animal imaging has been recognized as an important tool in preclinical research. Nevertheless, the results of non-invasive imaging are often disappointing owing to choice of a suboptimal imaging modality and/or shortcomings in study design, experime
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Fabian Kiessling • Bernd J. Pichler (Editors) Peter Hauff (Co-Editor)
Small Animal Imaging Basics and Practical Guide
Editors Prof. Dr. Fabian Kiessling Chair of Experimental Molecular Imaging University of Aachen (RWTH) Pauwelsstraße 20 52074 Aachen Germany [email protected] Prof. Dr. Bernd J. Pichler Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation Department of Radiology Eberhard Karls University of Tübingen Röntgenweg 13 72076 Tübingen GERMANY [email protected]
Co-Editor PD Dr. Peter Hauff Bayer Schering Pharma AG Global Drug Discovery TRG Diagnostic Imaging Müllerstr. 178 13353 Berlin Germany [email protected]
e-ISBN 978-3-642-12945-2 ISBN 978-3-642-12944-5 DOI 10.1007/978-3-642-12945-2 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2010936069 © Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: eStudioCalamar, Figueres/Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
During the last decade there have been tremendous advances in molecular biology and many important regulatory pathways of diseases have been identified. Along with these, genomics and proteomics are currently being implemented as important tools in the clinical workflow. On the other hand, there has been significant progress in non-invasive imaging technologies. Nowadays it is possible to scan an entire patient by CT and MRI with high spatial resolution and with exquisite tissue contrast within seconds or minutes. Contrast agents can be applied and their accumulation monitored dynamically to gain functional data about tissue vascularisation, perfusion and permeability. In addition, imaging modalities that are highly sensitive to administered radiolabelled probes like PET and SPECT enable us to elucidate changes in metabolism and proliferation as well as in molecular profiles of tissues with high sen
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