Genomic Medicine A Practical Guide
The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that
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Genomic Medicine
Laura J. Tafe • Maria E. Arcila Editors
Genomic Medicine A Practical Guide
Editors Laura J. Tafe Dartmouth–Hitchcock Medical Center Lebanon, NH USA
Maria E. Arcila Memorial Sloan Kettering Cancer Center New York, NY USA
ISBN 978-3-030-22921-4 ISBN 978-3-030-22922-1 (eBook) https://doi.org/10.1007/978-3-030-22922-1 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Molecular pathology is a rapidly evolving scientific discipline that encompasses the development of molecular and genetic approaches to the diagnosis, classification, monitoring, and risk assessment of human diseases. At the core of this discipline is the application of classical, novel, and cutting-edge technologies, developed in biochemistry, cell biology, molecular biology, proteomics, genetics, and bioinformatics, to the evaluation of pathologic processes. With the advent of high-throughput technology in recent years, the evolution of the field has gained such momentum, where it is difficult for the general pathologist, the clinician in practice, or young physicians in training to keep up with even the most basic concepts. While the information is readily available through various sources, it is extensive and is often difficult to find a central location with the “nuts and bolts” for quick reference. As molecular fellows, we both looked for the ideal high-yield reference book that would compile critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subspecialties. We hoped for a book to be succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interes
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