Spectrophotometric and visual determination of zoledronic acid by using a bacterial cell-derived nanopaper doped with cu
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ORIGINAL PAPER
Spectrophotometric and visual determination of zoledronic acid by using a bacterial cell-derived nanopaper doped with curcumin Shadab Faham 1 & Raouf Ghavami 1
&
Hamed Golmohammadi 2 & Gholamreza Khayatian 1
Received: 24 April 2019 / Accepted: 12 September 2019 # Springer-Verlag GmbH Austria, part of Springer Nature 2019
Abstract A nanopaper-based analytical device (NAD) is described for a colorimetric metal-complexing indicator-displacement assay (MIDA) for zoledronic acid (ZA). Bacterial cellulose nanopaper was doped with curcumin to obtain a chemosensor on which hydrophilic test zones were patterned via laser printing of hydrophobic walls. The color intensity of the test zones decreases in the presence of Fe(III) due to the formation of Fe(III)-curcumin complex. However, upon addition of ZA, Fe(III) ions preferably binds ZA. Subsequently, the color of the zone changes from light yellow to dark yellow. The changes in the absorption (measured at 427 nm) and of the color of the test stripe can be monitored visually, by using a digital camera, or by a spectrophotometer. Under optimal conditions, the analytical signals increase linearly in the 0.01–100 μM ZA concentration range, and the detection limits are 8.8 and 8.0 nM for smartphone and spectrophotometer-based methods, respectively. The method was employed to the determination of ZA in (spiked) urine, serum, saliva, and in pharmaceutical samples. Keywords Cellulose nanopaper . Colorimetric . Curcumin . Zoledronic acid
Introduction Zoledronic acid (ZA), a bisphosphonate drug, is widely used for treatment bone diseases and bone metastases in patients with breast cancer, prostate cancer, or multiple myeloma and also to reduce the hypercalcemia in those with bone metastases. ZA reduces skeletal-related events in patients with multiple myeloma [1–3]. ZA is a common agent for the treatment of osteoporosis by inhibiting osteoclasts and inducing apoptotic cell death in osteoclasts [4]. Comito et al. reported that treatment with ZA reduces macrophage-induced angiogenesis and tumor invasion in prostate cancer [5]. ZA reduces bone tumor Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-019-3815-9) contains supplementary material, which is available to authorized users. * Raouf Ghavami [email protected]; [email protected] * Hamed Golmohammadi [email protected]; [email protected] 1
Chemistry Department, Faculty of Science, University of Kurdistan, P.O. Box 416, Sanandaj 66177-15175, Iran
2
Chemistry and Chemical Engineering Research Center of Iran, Tehran 14335-186, Iran
burden in patients with bone metastases from breast cancer [6]. Honda et al. determine the relation between bone metabolism markers and clinical outcome in hepatocellular carcinoma patients treated with ZA [7]. Despite beneficial properties of ZA, it is toxic at high concentration levels in the body and can potentially lead to some side effects namely, osteonecrosis of the jaw, nephrotoxicity and hypocalcemia fo
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