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State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of Multiple Sclerosis Marı´a Jose´ Sa´ . Ricardo Soares dos Reis . Ayse Altintas . Elisabeth Gulowsen Celius . Claudia Chien . Giancarlo Comi . Francesc Graus . Jan Hillert . Jeremy Hobart . Gulfaraz Khan . Najib Kissani . Dawn Langdon . Maria Isabel Leite . Darin T. Okuda . Jacqueline Palace . Regina Marı´a Papais-Alvarenga . Ineˆs Mendes-Pinto . Fu-Dong Shi

Received: May 11, 2020 Ó The Author(s) 2020

ABSTRACT The 5th International Porto Congress of Multiple Sclerosis took place between the 14th and 16th of February 2019 in Porto, Portugal. Its intensive programme covered a wide-range of Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12594623. M. J. Sa´ (&)
R. Soares dos Reis (&) Department of Neurology, Centro Hospitalar Universita´rio de Sa˜o Joa˜o, Alameda Prof. Herna´ni Monteiro, Porto, Portugal e-mail: [email protected]. Soares dos Reis e-mail: [email protected] M. J. Sa´ Faculty of Health Sciences, University Fernando Pessoa, Rua Carlos da Maia, Porto, Portugal R. Soares dos Reis Department of Clinical Neurosciences and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal A. Altintas Department of Neurology, School of Medicine, Koc¸ University, Istanbul, Turkey E. G. Celius Department of Neurology, Oslo University Hospital, Ulleva˚l, Oslo, Norway E. G. Celius Institute of Clinical Medicine, University of Oslo, Oslo, Norway

themes—including many of the hot topics, challenges, pitfalls and yet unmet needs in the field of multiple sclerosis (MS)—led by a number of well-acknowledged world experts. This meeting review summarizes the talks that took place during the congress, which focussed on issues in MS as diverse as the development and challenges of progressive MS, epidemiology, differential diagnosis, medical management, molecular research and imaging tools. C. Chien NeuroCure Clinical Research Center, NeuroCure Cluster of Excellence, Charite´-Universita¨tsmedizin Berlin, Berlin, Germany G. Comi Department of Neurology, University Vita-Salute San Raffaele, Milan, Italy F. Graus Department of Neurology, August Pi i Sunyer Biomedical Research Institute (IDIBAPS) Hospital Clı´nic, Barcelona, Spain J. Hillert Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden J. Hobart Department of Neurology, University Hospitals Plymouth, Plymouth, UK J. Hobart Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK

Neurol Ther

Keywords: Congress review; Demyelinating diseases; Multiple sclerosis; Neurological diseases

Key Summary Points Multiple sclerosis (MS) is an immunedriven neurological disease with a conspicuously heterogeneous distribution that affects approximately 2.3 million people worldwide. The 5th International Porto Congress of Multiple Sclerosis took place on February 2019 in the city of Porto, Portugal, and brought toge