Statistical Human Genetics Methods and Protocols

The aim of this volume is to make computer programs for analyzing human genetic data more easily accessible to the beginner.Statistical Human Genetics: Methods and Protocols, Second Edition provides updated and new chapters detailing genetic terms, a

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Robert C. Elston Editor

Statistical Human Genetics Methods and Protocols Second Edition

METHODS

IN

MOLECULAR BIOLOGY

Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK

For further volumes: http://www.springer.com/series/7651

Statistical Human Genetics Methods and Protocols Second Edition

Edited by

Robert C. Elston Case Western Reserve University, Cleveland, Ohio, USA

Editor Robert C. Elston Case Western Reserve University Cleveland, Ohio, USA

ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7273-9 ISBN 978-1-4939-7274-6 (eBook) DOI 10.1007/978-1-4939-7274-6 Library of Congress Control Number: 2017951222 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.

Preface The recent advances in genetics, especially in the molecular techniques that have over the last quarter of a century spectacularly reduced the cost of determining genetic markers, open up a field of research that is becoming of increasing help in detecting, preventing, and/or curing many diseases that afflict us. This has brought with it the need for novel methods of statistical analysis and the implementation of these methods in a wide variety of computer programs. The aim in this book is to make these methods and programs more easily accessible to the beginner who has data to analyze, whether a student or a senior investigator. Twenty-eight of the thirty original chapters have been retained (all updated) and, in view of changes in the field, three new chapters have been added. Apart from the first chapter,