Stem Cell-Derived Models in Toxicology
This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous car
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Mike Clements Liz Roquemore Editors
Stem CellDerived Models in Toxicology
METHODS
IN
AND
PHARMACOLOGY
TOXICOLOGY
Series Editor Y. James Kang University of Louisville School of Medicine Prospect, Kentucky, USA
For further volumes: http://www.springer.com/series/7653
Stem Cell-Derived Models in Toxicology Edited by
Mike Clements Axion BioSystems, Inc., Atlanta, GA, USA
Liz Roquemore Cell Applications, GE Healthcare, Cardiff, UK
Editors Mike Clements Axion BioSystems, Inc. Atlanta, GA, USA
Liz Roquemore Cell Applications GE Healthcare Cardiff, UK
Videos can also be accessed at http://link.springer.com/book/10.1007/978-1-4939-6661-5 ISSN 1557-2153 ISSN 1940-6053 (electronic) Methods in Pharmacology and Toxicology ISBN 978-1-4939-6659-2 ISBN 978-1-4939-6661-5 (eBook) DOI 10.1007/978-1-4939-6661-5 Library of Congress Control Number: 2016957355 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Cover Illustration: Confocal microscopy image of a spheroid microtissue of hiPSC-derived cardiomyocytes (Cellular Dynamics International, Madison, USA) and human umbilical vein endothelial cells (Zen-Bio Inc., Durham, USA) produced using the GravityTrap hanging drop method (InSphero AG, Schlieren, Switzerland), and immunostained for von Willebrand factor (green), sarcomeric protein myomesin (red), and DNA (blue); from Chapter 11, Zuppinger. Overlaid is a field potential transient signal recorded from spontaneously beating hSC-derived cardiomyocytes on the multielectrode array (MEA) platform (Axion BioSystems Inc., Atlanta, USA); from Preface, Clements. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Unexpected adverse toxicity findings in drug development or postlaunch have resulted in numerous costly late-stage drug development failures and ma
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