Suppression and Regulation of Immune Responses Methods and Protocols
This second volume expands upon the previous edition with new research and objectives in immunoregulation and immune tolerance. Chapters cover topics ranging from new molecular and cellular mechanisms of tolerance; generation and characterization of mice
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Maria Cristina Cuturi Ignacio Anegon Editors
Suppression and Regulation of Immune Responses Methods and Protocols Volume II
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Suppression and Regulation of Immune Responses Methods and Protocols, Volume II
Edited by
Maria Cristina Cuturi and Ignacio Anegon INSERM UMR 1064-ITUN, Nantes, France
Editors Maria Cristina Cuturi INSERM UMR 1064-ITUN Nantes, France
Ignacio Anegon INSERM UMR 1064-ITUN Nantes, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3138-5 ISBN 978-1-4939-3139-2 (eBook) DOI 10.1007/978-1-4939-3139-2 Library of Congress Control Number: 2010936185 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Dedication Al Pepe Mujica, ejemplo de explorador de nuevos caminos.
Preface New Roads for Immune Tolerance: Finding the Way Caminante no hay camino, se hace camino al andar. Antonio Machado
This book describes new ways to induce immune immunoregulation and tolerance. The epigraph underlines that the roads taken in research are not defined in advance and unwind whilst moving ahead. This may seem obvious but underscores some interesting points of present research. One is that basic research, without a final goal or a given objective but rather curiosity-driven, needs to be preserved and stimulated as a way to find new paths of progress. Another point is the need to have a very open mind to options that emerge during research and find the one that may seem the most appropriate to choose. Finally, once on the road to immunoregulation or imm
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