The Immune Synapse Methods and Protocols
This volume provides all the essential protocols that are currently used to study the immune synapse. Chapters in The Immune Synapse: Methods and Protocols cover methods for the study of the dynamics of immune synapse assembly, traffic at the im
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Cosima T. Baldari Michael L. Dustin Editors
The Immune Synapse Methods and Protocols
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
The Immune Synapse Methods and Protocols
Edited by
Cosima T. Baldari Department of Life sciences, University of Siena, Siena, Siena, Italy
Michael L. Dustin University of Oxford, Kennedy Institute of Rheumatology, Headington, Oxford, UK
Editors Cosima T. Baldari Department of Life sciences University of Siena Siena, Siena, Italy
Michael L. Dustin University of Oxford, Kennedy Institute of Rheumatology Headington, Oxford, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6879-4 ISBN 978-1-4939-6881-7 (eBook) DOI 10.1007/978-1-4939-6881-7 Library of Congress Control Number: 2017931687 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Initiation of the T cell-mediated adaptive immune response to pathogens is crucially dependent on the assembly of a highly specialized signaling platform that forms at the interface of a T cell and an antigen-presenting cell (APC) bearing specific peptide antigen associated with major histocompatibility molecules, known as the immune synapse. From its initial description as a membrane domain characterized by the segregation in concentric subdomains of specific receptors that is accompanied by the polarization of the microtubule- organizing center towards the APC contact area, our understanding of th
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