Suxamethonium chloride

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Bradycardia: case report A 21-year old man developed severe bradycardia after receiving suxamethonium chloride prior to electroconvulsive therapy (ECT). The man, who had a diagnosis of schizophrenia and marijuana abuse, and who was receiving clozapine, initiated ECT. Pre-ECT anaesthesia consisted of IV suxamethonium chloride 90mg, metoclopramide, glycopyrrolate, alfentanil and etomidate. Pre-induction ECG showed a HR of 92 beats/min. Approximately 15 seconds after receiving suxamethonium chloride, he developed severe bradycardia (30 bpm) which normalised to 76 bpm after administration of atropine. He received ECT without further sequelae. During his second and third ECT sessions, he again developed bradycardia after receiving IV suxamethonium 90 mg. From the fourth session, suxamethonium chloride was replaced with mivacurium chloride. Apart from the third and fourth sessions, atropine was not required. He received nine further ECT treatments, without bradycardia. Author comment: "The fact that once [suxamethonium chloride] had been replaced by mivacurium, our patient received an additional 9 ECT sessions without bradycardia is suggestive of a [suxamethonium chloride]-related bradycardia." Birkenhager TK, et al. Severe bradycardia after anesthesia before electroconvulsive therapy. Journal of ECT 26: 53-54, No. 1, Mar 2010. Available from: URL: http:// 803013948 dx.doi.org/10.1097/yct.0b013e3181b00f5b - Netherlands

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Reactions 15 May 2010 No. 1301