Synaptic Plasticity Dynamics, Development and Disease
This book introduces the current concepts of molecular mechanisms in synaptic plasticity and provides a comprehensive overview of cutting-edge research technology used to investigate the molecular dynamics of the synapses. It explores current concepts on
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Michael R. Kreutz
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Carlo Sala
Editors
Synaptic Plasticity Dynamics, Development and Disease
Editors Dr. Michael R. Kreutz Leibniz Institute for Neurobiology PG Neuroplasticity Magdeburg Germany [email protected]
Dr. Carlo Sala Institute of Neuroscience CNR, National Research Council Milano Italy [email protected]
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Preface
Synapses are sites of a specialized cell-cell contact between neuronal cells and represent the major structure involved in chemical neurotransmission in the nervous system. It is widely believed that glutamatergic synapses are important loci for modifying the functional properties of CNS networks, possibly providing the basis for phenomena collectively referred to as “learning and memory”. Given their importance, it is not surprising that enormous efforts are being made to understand the formation, structure, function and regulation of glutamatergic synapses. To date, significant progress has been made in our understanding of their ultrastructure, molecular composition, and physiological properties, as well as the principles of how these synapses are initially assembled and “plastically” modified. The term synaptic plasticity covers many different aspects of use-dependent synaptic modifications and is commonly used in a broader sense describing aspects of synaptic signal transmission as well as structural alterations in the molecular make-up of the synapse related to synaptic signaling events. The capacity of the nervous system to modify its own organization is remarkable; plastic changes can occur as a consequence of many events, including the normal development and maturation of the organism, the acquisition of new skills (‘learning’) and after brain damage. This response specificity is not always intrinsic to neurons; rather, it can develop
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