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Synthesis of Zinc Oxide Nanoparticles Coated with Silicon Oxide V. V. Butovaa,b,*, V. A. Polyakova,b, E. A. Erofeevaa, Zhengyou Lia, M. A. Soldatova,b, and A. V. Soldatova Presented by Academician V.I. Minkin February 19, 2020 Received February 19, 2020; revised April 14, 2020; accepted May 25, 2020

Abstract—The new technique of synthesis of zinc oxide nanoparticles for biomedical applications is reported. As a precursor, the metal-organic framework ZIF-8 was used, on the basis of which zinc oxide nanoparticles of size 20‒30 nm were obtained. Moreover, a porous ZIF-8 structure was used for the introduction of a silicon source. As a result, after thermal decomposition, zinc oxide nanoparticles with 5‒6 nm size coated by the SiO2 layer were obtained. Synthesized materials were comprehensively characterized. Keywords: nanoparticles, ZIF-8, zeolites, photodynamic therapy, porous materials DOI: 10.1134/S0012500820050018

Photodynamic therapy (PDT) is an effective method for cancer diagnosis and treatment [1]. PDT is based on the use of photosensitizers accumulated mainly in pathological tissue. The interaction of the photosensitizer and light leads to the formation of cytotoxic particles, including singlet oxygen, which are characterized by a short lifetime (