Systems Biology

In this volume, a wide-ranging series of reviews reveal how systems biology—a holistic and inter-disciplinary approach requiring the combined talents of biologists, mathematicians, and computer scientists—is changing the face of infectious disease researc

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Series Editors Klaus Aktories Medizinische Fakultät, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Abt. I AlbertLudwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany Richard W. Compans Department of Microbiology and Immunology, Emory University, 1518 Clifton Road, CNR 5005, Atlanta, GA 30322, USA Max D. Cooper Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462 Clifton Road, Atlanta, GA 30322, USA Jorge E. Galan Boyer Ctr. for Molecular Medicine, School of Medicine, Yale University, 295 Congress Avenue, room 343, New Haven, CT, 06536-0812, USA Yuri Y. Gleba ICON Genetics AG, Biozentrum Halle, Weinbergweg 22, 06120 Halle, Germany Tasuku Honjo Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Sakyo-ku, Yoshida, Kyoto 606-8501, Japan Yoshihiro Kawaoka School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA Bernard Malissen Centre d’Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France Fritz Melchers Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany Michael B. A. Oldstone Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Rino Rappuoli Novartis Vaccines, Via Fiorentina 1, Siena, 53100, Italy Peter K. Vogt Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-239, La Jolla, CA 92037, USA Honorary Editor: Hilary Koprowski Biotechnology Foundation, Inc., 119 Sibley Avenue, Ardmore, PA 19003, USA

Current Topics in Microbiology and Immunology Previously published volumes Further volumes can be found at www.springer.com Vol. 332: Karasev A. (Ed.): Plant produced Microbial Vaccines. 2009. ISBN 978-3-540-70857-5 Vol. 333: Compans, Richard W.; Orenstein, Walter A. (Eds.): Vaccines for Pandemic Influenza. 2009. ISBN 978-3-540-92164-6 Vol. 334: McGavern, Dorian; Dustin, Micheal (Eds.): Visualizing Immunity. 2009. ISBN 978-3-540-93862-0 Vol. 335: Levine, Beth; Yoshimori, Tamotsu; Deretic, Vojo (Eds.): Autophagy in Infection and Immunity. 2009. ISBN 978-3-642-00301-1 Vol. 336: Kielian, Tammy (Ed.): Toll-like Receptors: Roles in Infection and Neuropathology. 2009. ISBN 978-3-642-00548-0 Vol. 337: Sasakawa, Chihiro (Ed.): Molecular Mechanisms of Bacterial Infection via the Gut. 2009. ISBN 978-3-642-01845-9 Vol. 338: Rothman, Alan L. (Ed.): Dengue Virus. 2009. ISBN 978-3-642-02214-2 Vol. 339: Spearman, Paul; Freed, Eric O. (Eds.): HIV Interactions with Host Cell Proteins. 2009. ISBN 978-3-642-02174-9 Vol. 340: Saito, Takashi; Batista, Facundo D. (Eds.): Immunological Synapse. 2010. ISBN 978-3-642-03857-0 Vol. 341: Bruserud, Øystein (Ed.): The Chemokine System in Clinical and Experimental Hematology. 2010. ISBN 978-3-642-12638-3 Vol. 342: Arvin, Ann M. (Ed.): Varicella-zoster Virus. 2010. ISBN 978-3-642-12727-4 Vol. 343: Johnson, John E. (Ed.): Cell