Evolutionary Systems Biology
The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of obse
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Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan
For further volumes: www.springer.com/series/5584
Orkun S. Soyer Editor
Evolutionary Systems Biology
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Editor Orkun S. Soyer University of Exeter Exeter, Devon, UK
ISSN 0065-2598 ISBN 978-1-4614-3566-2 ISBN 978-1-4614-3567-9 (eBook) DOI 10.1007/978-1-4614-3567-9 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012940413 © Springer Science+Business Media, LLC 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Evolutionary Systems Biology is an emerging field and a scientific synthesis in the making. There is currently no single definition that captures all the facets of this fastdeveloping field (as discussed below, there may never be one). There is, however, one binding aim at the core of this synthesis to understand better the genotype– phenotype mapping at the cellular level and its evolution. The abstract notions of genotype and phenotype were first proposed by geneticist Wilhelm Johannsen to describe broadly the low-level mechanisms and their higher level manifestations in biological systems. These abst
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