Systems Biology
This volume focuses on methodological aspects of systems biology in order to provide a new theoretical approach with a robust and tailored experimental support. Chapters detail mathematical modeling, methodological issues, modulation of the collective beh
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Mariano Bizzarri Editor
Systems Biology
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Systems Biology Edited by
Mariano Bizzarri Department of Experimental Medicine, Systems Biology Group Lab Sapienza University of Rome, Rome, Italy
Editor Mariano Bizzarri Department of Experimental Medicine Systems Biology Group Lab Sapienza University of Rome Rome, Italy
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7455-9 ISBN 978-1-4939-7456-6 (eBook) https://doi.org/10.1007/978-1-4939-7456-6 Library of Congress Control Number: 2017957710 © Springer Science+Business Media LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Challenges and Promises of Systems Biology: Methodological Issues There are many definitions striving to capture the hidden meaning of “Systems Biology.” Indeed, despite many efforts, the concept of Systems Biology remains quite uncertain. As already highlighted [1], currently two primary streams can be recognized within Systems Biology: (1) pragmatic Systems Biology, which emphasizes the use of large-scale molecular interactions (“omic” approach), aimed at building huge signaling networks by applying mathematical modeling, and thus showing how cells make decisions based on the “information” flowing through their networks. (2) Theoretic Systems Biology which posits that the theoretical (and consequently the methodological) basis of biological study should be deeply modified [2]. Molecular Biol
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