Systems Biology
A comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering, this volume presents an overall picture of the current topics central to structural and functional genomics, proteomics, metabolomics and b
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C ELL E NGINE E R ING 5
Systems Biology
Cell Engineering
Cell Engineering Volume 5 Editor-in-Chief Professor Mohamed Al-Rubeai University College Dublin, Belfield, Dublin, Ireland Editorial Board Dr Hansjorg Hauser GBF, Braunschweig, Germany Professor Michael Betenbaugh Johns Hopkins University, Baltimore, U.S.A. Professor Martin Fussenegger Swiss Federal Institute of Technology, Zurich, Switzerland Dr Nigel Jenkins Serono Biotech Centre, Fenil-sur-Corsier, Switzerland Dr Otto-Wilhelm Merten A.F.M.-Genethon 11, Gene Therapy Program, Evry, France
The titles published in this series are listed at the end of this volume
CELL ENGINEERING Vol. 5: Systems Biology Edited by
Mohamed Al-Rubeai University College Dublin, Ireland and
Martin Fussenegger Swiss Federal Institute of Technology, ETH Hoenggeerberg HCI Institute of Chemical and Bioengineering ICB, Zurich, Switzerland
A C.I.P. Catalogue record for this book is available from the Library of Congress.
ISBN-10 ISBN-13 ISBN-10 ISBN-13
1-4020-5251-0 (HB) 978-1-4020-5251-4 (HB) 1-4020-5252-9 (e-book) 978-1-4020-5252-1 (e-book)
Published by Springer, P.O. Box 17, 3300 AA Dordrecht, The Netherlands. www.springer.com
Printed on acid-free paper
All Rights Reserved © 2007 Springer No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work.
CONTENTS
List of Contributors
vii
1.
Structural Genomics: A Special Emphasis on Membrane Proteins Kenneth Lundstrom
1
2.
RNA Interference in Haematopoietic and Leukaemic Cells Maria Thomas, Natalia Martínez Soria and Olaf Heidenreich
29
3.
Genomics and Proteomics of Chinese Hamster Ovary (CHO) Cells Peter Morin Nissom and Robin Philp
49
4.
The Unfolded Protein Response Natalie Strudwick and Martin Schröder
69
5.
Engineering of Cell Proliferation via myc Modulation Vasiliki Ifandi and Mohamed Al-Rubeai
6.
The Molecular Response(s) during Cellular Adaptation to, and Recovery from, Sub-Physiological Temperatures Sarah J Scott, Rosalyn J Marchant, Mohamed B Al-Fageeh, Michèle F Underhill, and C Mark Smales
157
185
7.
Molecular Response to Osmotic Shock Susan T. Sharfstein, Duan Shen, Thomas R. Kiehl and Rui Zhou
213
8.
Metabolomics Soo Hean Gary Khoo and Mohamed Al-Rubeai
237
9.
Metabolic Flux Analysis of Mammalian Cells D.E. Martens
275
10. Metabolic Engineering Effendi Leonard, Zachary L. Fowler and Mattheos Koffas v
301
vi
CONTENTS
11. Chemical Organisation Theory Peter Dittrich and Pietro Speroni di Fenizio
361
12. Prokaryotic Systems Biology Amy K. Schmid and Nitin S. Baliga
395
LIST OF CONTRIBUTORS
Mohamed B. Al-Fageeh University of Kent Canterbury, UK
Mattheos Koffas State University of New York at Buffalo Buffalo, NY, USA
Mohamed
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