Systems Metabolic Engineering
Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology, it enables the global analysis a
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Christoph Wittmann
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Sang Yup Lee
Editors
Systems Metabolic Engineering
Editors Christoph Wittmann Institute of Biochemical Engineering Braunschweig Integrated Center for Systems Biology (BRICS) Center for Pharmaceutical Engineering Technische Universita¨t Braunschweig Braunschweig, Germany
Sang Yup Lee Metabolic and Biomolecular Engineering National Research Laboratory Department of Chemical and Biomolecular Engineering (BK21 Program) Center for Systems and Synthetic Biotechnology Institute for the BioCentury KAIST Daejeon, Republic of Korea
ISBN 978-94-007-4533-9 ISBN 978-94-007-4534-6 (eBook) DOI 10.1007/978-94-007-4534-6 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2012941228 # Springer Science+Business Media Dordrecht 2012
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To Heike, Isabelle, Felix and Florian from Christoph and to Hyejean and Gina from Sang Yup for their love, support and inspiration
Preface
The integration of systems-wide omics approaches, genome-scale modeling and simulation, synthetic biological approaches, and even evolutionary engineering is opening a new era of industrial strain engineering – the design-based creation of tailor-made overproducers that are optimized at the global level. Thi
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