Metabolic Engineering for Bioprocess Commercialization
This volume reviews the current metabolic engineering tools and technologies from a practical point of view, and guides researchers as they overcome challenges at various stages of organism and bioprocess development. Microbes have been engineered to prod
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Metabolic Engineering for Bioprocess Commercialization
Metabolic Engineering for Bioprocess Commercialization
Stephen Van Dien Editor
Metabolic Engineering for Bioprocess Commercialization
123
Editor Stephen Van Dien Genomatica, Inc. San Diego, CA USA
ISBN 978-3-319-41964-0 DOI 10.1007/978-3-319-41966-4
ISBN 978-3-319-41966-4
(eBook)
Library of Congress Control Number: 2016943877 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Stephen Van Dien
1
2 Gene Expression Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Nicholas J. Morse and Hal S. Alper
7
3 Heterologous Pathway Engineering. . . . . . . . . . . . . . . . . . . . . . . . . Wei Niu, Jiantao Guo and Steve Van Dien
31
4 Leveraging Gene Synthesis, Advanced Cloning Techniques, and Machine Learning for Metabolic Pathway Engineering. . . . . . . Kedar G. Patel, Mark Welch and Claes Gustafsson
53
5 Tolerance of Microbial Biocatalysts to Feedstocks, Products, and Environmental Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mian Huang, George Peabody and Katy C. Kao
73
6 Biobased Technology Commercialization: The Importance of Lab to Pilot Scale-up . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 James P. Wynn, Robert Hanchar, Susanne Kleff, David Senyk and Tonya Tiedje Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121
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Chapter 1
Introduction Stephen Van Dien
Abstract The field of metabolic engineering, loosely defined as the manipulation of living organisms to achieve a desired metabolic objective, has grown and advanced significantly over the past 20 years. First applied to im
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