The cytoskeleton in Alzheimer disease
The strongest physical correlate with the severity of dementia in Alzheimer’s disease and its most rational cause are the loss of neocortical and hippocampal synapses. Evidence, showing that β-amyloid causes that loss is weak despite the popularity of tha
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K. Jellinger F. Fazekas M. Windisch (eds.) Ageing and Dementia
Springer-Verlag Wien GmbH
Prof. Dr. K. Jellinger Ludwig-Boltzmann-Institut fUr Klinische Neurobiologie, Wien, Osterreich
Prof. Dr. F. Fazekas Universitătsklinik fUr Neurologie, Graz, Osterreich
Dr. M. Windisch Institut fUr Experimentelle Pharmakologie, Forschungsinitiative EBEWE, Graz, Osterreich
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. © 1998 Springer-Verlag Wien Originally published by Springer-Verlag Wien New York in 1998 Softcover reprint ofthe hardcover Ist edition 1998 Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
Printed on acid-free and chlorine-free bleached paper SPIN: 10673033
With 65 (partly coloured) Figures
ISBN 978-3-211-83114-4 ISBN 978-3-7091-6467-9 (eBook) DOI 10.1007/978-3-7091-6467-9
Foreword Ageing and Dementia are closely related conditions as we know from the increasing frequency of dementing disorders in later life. However, significant cognitive impairment is not necessarily a consequence of advancing age. Considering the increasing life expectancy of our population it is one of the great challenges of medicine to identify those factors which obviate successful ageing and to search for possibilities of intervention. Epidemiologic studies including extensive neurodiagnostic, biochemical, and genetic assessment are the tools to delineate the differences between normal and pathologic age-associated changes. Progressively refined techniques of analysing postmortem brain tissue enhance our understanding of the various dementing disorders. Finally, all these informations and the results of experimental work may lead to new treatment strategies. In spite of considerable progress in molecular genetics, biochemistry, and neuropathology, the etiology and pathogenesis of Alzheimer's disease and other dementing disorders are still unknown. Diagnosis is frequently made only at postmortem. Because specific disease markers are not available for the majority of dementias, consensus criteria for the identification of such disorders are warranted. These criteria could serve at a basis for early diagnosis and distinction from other dementing disorders. The present volume includes the papers and posters presented at the 5th International Symposium of the Research Initiative EBEWE, held in October 17 -19, 1997 in Graz. This international workshop was intended
