The Cytoskeleton in Health and Disease
This volume explores the cytoskeleton, examining its structural and functional roles and its dysfunctions which often lead to disease. Microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different
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The Cytoskeleton in Health and Disease
The Cytoskeleton in Health and Disease
Heide Schatten Editor
The Cytoskeleton in Health and Disease
Editor Heide Schatten Department of Veterinary Pathobiology University of Missouri-Columbia Columbia, MO, USA
ISBN 978-1-4939-2903-0 ISBN 978-1-4939-2904-7 DOI 10.1007/978-1-4939-2904-7
(eBook)
Library of Congress Control Number: 2015945026 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www. springer.com)
Preface
New research on the cytoskeleton has led to exciting new data on its functions and dysfunctions in health and disease, and it has allowed a more complete understanding of cytoskeletal interactions in various cell organizations. Cytoskeletal functions are essential for numerous cellular activities including cellular signaling, cell migration, cell division, transport of macromolecular complexes, and cell organelles that play a role in cellular metabolism, and various others, while cytoskeletal dysfunctions lead to a wide range of disorders and diseases such as cancer, Alzheimer’s, neurodegenerative disorders, reproductive disorders, and a variety of metabolic disorders. Much progress has been made in recent years to develop new strategies that target specific cytoskeletal dysfunctions with the goal to restore normal functions; other studies have been focused on inhibiting abnormal cytoskeletal activities to control cancer cell proliferation. New drugs are being developed to target cytoskeletal abnormalities on cell and molecular levels which include targeting cytoskeletonassociated proteins and posttranslational modifications. This book covers recent advances in the cytoskeletal field and new discoveries that have emerged during the past few years related to the three major cytoskeletal components, microtubules,
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