The Environmental and Human Effects of Ptaquiloside-Induced Enzootic Bovine Hematuria: A Tumorous Disease of Cattle

Enzootic bovine hematuria (EBH) is a disease of cattle that is characterized by the intermittent presence of blood in urine caused by malignant lesions in the urinary bladder. The disease causes anemia, progressive emaciation, and death (Jones and Hunt 19

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Contents 1 Introduction ........................................................................................................................ 2 Enzootic Localities and Incidence ..................................................................................... 3 Clinical Symptoms............................................................................................................. 4 Etiology.............................................................................................................................. 4.1 Bracken and Other Ferns .......................................................................................... 4.2 Bovine Papillomavirus .............................................................................................. 4.3 Interaction of Bracken Fern and Bovine Papillomavirus .......................................... 5 Pathology............................................................................................................................ 6 Experimental Animal Models ............................................................................................ 7 Effects on Human Health ................................................................................................... 7.1 Ptaquiloside in the Human Food Chain .................................................................... 7.2 Effect of Ptaquiloside on Soil, and Surface, and Ground Water ............................... 8 Diagnosis............................................................................................................................ 8.1 Gene Mutations ......................................................................................................... 8.2 Immunohistochemical Expression of Tumor Biomarkers ........................................ 8.3 Chromosomal Aberrations ........................................................................................ 8.4 Oxidative Stress ........................................................................................................ 8.5 Ultrasonography........................................................................................................ 8.6 Polymerase Chain Reaction for Bovine Papillomavirus........................................... 8.7 Real-Time PCR for BPV........................................................................................... 8.8 DNase-SISPA for BPV.............................................................................................. 9 Prevention and Control ...................................................................................................... 10 Future Areas for Research .................................................................................................. 11 Summary . ........................................................................................................................... References ..................................................................................................................................

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