The Hepatitis C Viruses

Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much o

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Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama J.M. Hogle, Boston/Massachusetts· Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania· F. Melchers, Basel M. Oldstone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland· H. Saedler, Cologne P.K. Vogt, La lolla/California . H. Wagner, Munich

Springer Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Singapore Tokyo

The Hepatitis C Viruses Edited by C.H. Hagedorn and C.M. Rice

With 47 Figures and 15 Tables

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Springer

CURT H. HAGEDORN, M.D. Division of Digestive Diseases and Genetics - Winship Cancer Center

1639

Pierce Drive, Rm

2101

WMRB

Emory University School of Medicine Atlanta, GA

30322

USA CHARLES M. RICE, M.D. Washington University School of Medicine Department of Molecular Microbiology

600

South Euclid Avenue

St. Louis, MO

63110

USA

Cover Illustration: The map provides estimates of the worldwide prevalence of chronic hepatitis C (see DL Thomas; Hepatitis C Epidemiology). Contact [email protected] regarding the global collection of more precise data on hepatitis C epidemiology (see Weekly Epidemiological Record 1997, 72,341-348). Cover Design: design & production

GmbH, Heidelberg

ISSN 0070-217X ISBN-13: 978- 3-642- 64047-6 DOl: 10.1007/978-3-642-59605-6

e-ISBN-13: 978- 3- 642-596 05 -6

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Preface

Understanding the world we live in can be a challenging task. It is currently estimated that at least 170 million people are chronically infected with the hepatitis C virus (HCY). Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. Although HCY is perhaps an ancient hum