The immunohistochemical expression of von Willebrand factor, T-cadherin, and Caveolin-1 is increased in kidney allograft
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ORIGINAL ARTICLE
The immunohistochemical expression of von Willebrand factor, T‑cadherin, and Caveolin‑1 is increased in kidney allograft biopsies with antibody‑mediated injury André Costa Teixeira1,2 · Fábio Távora1,2 · Melissa Lou Fagundes de Deus e Silva3 · Renan Martins Gomes Prado3 · Ronaldo de Matos Esmeraldo4 · Tainá Veras de Sandes‑Freitas1,4 Received: 23 June 2020 / Accepted: 8 November 2020 © Japanese Society of Nephrology 2020
Abstract Background There are only a few reports evaluating the applicability of endothelial-damage markers analysis by immunohistochemistry (IHC) in kidney allograft samples. This study analyzed the expression of Caveolin-1 (Cav), von Willebrand factor (Vwf), and T-cadherin (Cad) in kidney biopsies and their association with antibody-mediated injury. Methods In this retrospective study, 114 cases with antibody-mediated changes (Banff, 2020) and 72 with interstitial fibrosis/ tubular atrophy were selected. IHC for Cav, Vwf and Cad was performed and evaluated according to their qualitative expression in peritubular capillaries. The cases were grouped according to the presence of microvascular inflammation (MVI), donor-specific antibodies (DSA), C4d positivity and antibody-mediated rejection (AMR). A level of significance
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