The Menopause and Postmenopause The Proceedings of an International
The treatment of menopausal and postmenopausal symptoms is a focus of considerable debate, on account of both the medical and social factors involved. And perhaps the cause of the greatest current interest and concern is not so much the effectiveness of p
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The Menopause and Postmenopause The Proceedings of an International Symposium held in Rome, June 1979
Edited by
N. Pasetto Patologia Ostetrica e Ginecologica, Universita di Roma, Italy R. Paoletti Istituto di Farmacologia, Universita di Milano, Italy and J. L. Ambrus Department of Health, Buffalo, New York, USA
University Park Press Baltimore
Published in USA and Canada by University Park Press 233 East Redwood Street Baltimore, Maryland 21202 Published in UK by MTP Press Limited Falcon House Lancaster, England Copyright © 1980 MTP Press Limited Softcover reprint of the hardcover 1st edition 1980 First published 1980 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers. ISBN-13: 978-94-011-7232-5 e-ISBN-13: 978-94-011-7230-1 DOl: 10.1007/978-94-011-7230-1 LCCN: 79-93427 Filmset by Mather Bros (Printers) Ltd, Preston, England
Contents List of contributors
IX
xiii
Preface Section I
Pharmacological update
I
Chemistry and biochemistry of natural estrogens R. Deghenghi
2
Estrogens and prostaglandins R. Paoletti and A. Poli
17
Plasma concentration of estrogens after application of various estrogen preparations A. E. Schindler, M. Zwirner, R. Caser and H. M. Bolt
25
Progestogen modification of estrogen-induced endometrial proliferation in climacteric women M. I. Whitehead, J. McQueen, J. Minardi and S. Campbell
31
New concepts of estrogenic activity: the role of metabolites in the expression of hormone action J. Fishman and C. P. Martucci
43
3
4
5
Section II 6 7
3
Clinical update
Hormonal influences on IX-adrenoreceptors: preliminary results K. Wood and A. Coppen
55
'Psychotherapeutic effects' of estrogen substitution during the climacteric period J. M. Wenderlein
63
v
CONTENTS
8
Double-blind studies on the effects of natural estrogens on postmenopausal women: a follow-up report P. T. Townsend, M. I. Whitehead, J. McQueen, J. Minardi and S. Campbell
75
9 Considerations concerning the clinical treatment of the principal micturitional disturbances of the postmenopause M. Maneschi, S. M. Rubino and V. Messana
85
10 The urethral syndrome - role of estrogens in the therapy P. Smith 11
12
13
14
15
16
17
18
91
Relationships of ovary, endometrium and vagina to estrogen therapy in the postmenopause S. Cianci and P. Boemi
107
Prolactin in postmenopausal endometrial hyperplasia and adenocarcmoma A. Volpe, P. P. Pellegri, F. Boselli, V. Mazza, A. Grasso, G. Maccarrone, A. GolesandG. D. Montanari
113
The prevention and treatment of endometrial pathology in postmenopausal women receiving exogenous estrogens J. W. W. Studd, M. H. Thom, M. E. L. Paterson and T. Wade-Evans
127
Treatment of patients at risk. Cross-over study between natural estrogens N. Pasetto. E. Piccione. F. Pasetto, L. Baschieri and R. Maturi
141
Estrogen therapy preparatory to vaginal surgery in advanced menopause G.
