The Nicotinic Acetylcholine Receptor Current Views and Future Trends
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Francisco J. Barrantes (Ed.)
The Nicotinic Acetylcholine Receptor: Current Views and Future Trends
Springer
Francisco
J. Barrantes
Instituto de Investigaciones Bioqufmicas de Bahfa Blanca Universidad Nacional del Sur Bahfa Blanca, Argentina
ISBN 978-3-662-39256-0 ISBN 978-3-662-40279-5 (eBook) DOI 10.1007/978-3-662-40279-5
Biotechnology Intelligence Unit Library of Congress Cataloging-in-Publication data The nicotinic acetylcholine receptor: current views and future trends 1 [edited by] Francisco Jose Barrantes. p. cm.--(Biotechno1ogy intelligence unit) Includes bibliographical references and index. ISBN 978-3-662-39256-0 1. Nicotinic receptors. 2. Acetylcholine--Receptors. I. Barrantes, Francisco Jose, 1944- . II. Series. [DNLM: 1. Receptors, Nicotinic--physiology. 2. Receptors. Cholinergic--physiology. WL 102.8 N6618 1997] QP364·7.N541997 612.8'14--dc21 DNLM/DLC for Library of Congress This work is subject to copyright. Ali rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1998 Originally published by Springer-Verlag Berlin Heidelberg New York and R.G. Landes Company Georgetown in 1998 Softcover reprint ofthe hardcover 1st edition 1998
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DEDICATION
To Phyllis
=====FOREWORD=====
O
ver the last two decades a convergence of techniques from various scientific disciplines has contributed to our comprehension of the structure, evolutionary trends and the multiplicity of functions performed by ligand- and voltage-gated ion channels and receptors. This book puts together in a well organized, comprehensive and yet succinct manner one of the fastest growing fields in the Molecular Neurosciences, that of the ligand-gated ion channels (LGIC). Several neurotransmitter receptors constitute this superfamily, the nicotinic acetylcholine receptor still being the prototype. The study of central nervous system (neuronal) acetylcholine receptors is generating growing
