The NMDA Receptors
This volume provides a history of and an update on the functional status of the NMDA receptors. The NMDA receptors are essential for neuronal development, synaptic plasticity, learning, and cell survival. It covers molecular, cellular, anatomical, biochem
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Kenji Hashimoto Editor
The NMDA Receptors
The Receptors
Volume 30
Series Editor Giuseppe di Giovanni Department of Physiology & Biochemistry Faculty of Medicine and Surgery University of Malta, Malta, Italy
The Receptors book Series, founded in the 1980s, is a broad-based and wellrespected series on all aspects of receptor neurophysiology. The series presents published volumes that comprehensively review neural receptors for a specific hormone or neurotransmitter by invited leading specialists. Particular attention is paid to in-depth studies of receptors’ role in health and neuropathological processes. Recent volumes in the series cover chemical, physical, modeling, biological, pharmacological, anatomical aspects and drug discovery regarding different receptors. All books in this series have, with a rigorous editing, a strong reference value and provide essential up-to-date resources for neuroscience researchers, lecturers, students and pharmaceutical research.
More information about this series at http://www.springer.com/series/7668
Kenji Hashimoto Editor
The NMDA Receptors
Editor Kenji Hashimoto Division of Clinical Neuroscience Chiba University Center for Forensic Mental Health Chiba, Japan
The Receptors ISBN 978-3-319-49793-8 ISBN 978-3-319-49795-2 (eBook) DOI 10.1007/978-3-319-49795-2 Library of Congress Control Number: 2016962311 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
History of NMDA Receptors
The research field of the excitatory amino acids, including l-glutamate and l- aspartate, had its origin in the discovery by Hayashi (1954) of the convulsive effects of
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