The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke
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The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke Ceren Eyileten 1 & Lucia Sharif 1 & Zofia Wicik 1,2 & Daniel Jakubik 1 & Joanna Jarosz-Popek 1 & Aleksandra Soplinska 1 & Marek Postula 1 & Anna Czlonkowska 3 & Agnieszka Kaplon-Cieslicka 4 & Dagmara Mirowska-Guzel 1 Received: 19 May 2020 / Accepted: 25 August 2020 # The Author(s) 2020
Abstract Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system (CNS), have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), multiple sclerosis (MS), and ischemic stroke. MicroRNAs (miRNAs) are a class of non-coding RNAs found in body fluids such as peripheral blood and cerebrospinal fluid. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of neurodegenerative and neurovascular diseases. Thus, they present as promising biomarkers and a novel treatment approach for CNS disorders. Currently, limited studies provide viable evidence of miRNA-mediated post-transcriptional regulation of BDNF. The aim of this review is to provide a comprehensive assessment of the current knowledge regarding the potential diagnostic and prognostic values of miRNAs affecting BDNF expression and its role as a CNS disorders and neurovascular disease biomarker. Moreover, a novel therapeutic approach in neurodegenerative diseases and ischemic stroke targeting miRNAs associated with BDNF will be discussed. Keywords Peripheral biomarker . Stroke . miRNA . Neurodegenerative disease . BDNF . Novel treatment . Neurotrophic factor . Neurotrophin . Neurovascular disease Highlights • For the first time, BDNF–miRNA interactions (the modulation of BDNF signaling by miRNAs) in selected neurodegenerative and neurovascular diseases were comprehensively discussed. • The importance of many miRNAs and the promising therapeutic value of ago/antagomiRs were reviewed in central nervous system disorders. * Dagmara Mirowska-Guzel [email protected]
Marek Postula [email protected]
Ceren Eyileten [email protected]
Anna Czlonkowska [email protected]
Lucia Sharif [email protected]
Agnieszka Kaplon-Cieslicka [email protected]
Zofia Wicik [email protected]
1
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., 02-097 Warsaw, Poland
2
Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Paulo, Brazil
Joanna Jarosz-Popek [email protected]
3
2nd Department of Neurology, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland
Al
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