The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese
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RESEARCH
Open Access
The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population Peng Huang1,2†, Haozhi Fan1†, Ting Tian1, Peiwen Liao3, Jun Li4, Rongbin Yu1, Xueshan Xia5, Yue Feng5, Jie Wang6, Yuan Liu4, Yun Zhang1,2 and Ming Yue4*
Abstract Background: Recently, human leukocyte antigen (HLA) class-II gene polymorphisms have been reported to be related to Hepatitis C virus (HCV) infection and chronicity. The objective of this study was to explore the relationship of HLA-DP rs9277535 and HLA-DQ rs7453920 with the outcomes of HCV infection. Methods: The rs9277535 and rs7453920 were genotyped in 370 subjects with chronic HCV infection, 194 subjects with spontaneous HCV clearance, and 973 subjects with non-HCV infection from the Chinese population using the ABI TaqMan allelic discrimination assay. Results: Logistic regression analyses showed that the minor allele A of rs7453920 significantly increased the susceptibility of HCV infection in dominant model (adjusted OR = 1.33, 95% CI: 1.04–1.71, P = 0.026) and additive models (adjusted OR = 1.30, 95% CI: 1.06–1.60, P = 0.012). Rs9277535 A allele significantly increased the risk of chronic HCV infection in dominant model (adjusted OR = 1.52, 95% CI: 1.01–2.28, P = 0.046). Haplotype AA showed a higher risk of HCV infection than the most frequent haplotype GG (adjusted OR = 1.37, 95% CI: 1.05–1.78, P = 0.018). Conclusion: The HLA-DQ rs7453920 and -DP rs9277535 mutations were significantly associated with HCV infection susceptibility and chronicity, respectively. Keywords: Hepatitis C virus, HLA, Gene polymorphism, Drug use, Hemodialysis, Paid blood donors
Background Hepatitis C virus (HCV) infection remains a major public health concern, although there has been significant progress in the treatment of HCV infection due to the presence of direct antiviral drugs (DAAs). Based on the estimation of the World Health Organization (WHO), there are 130–150 million people infected with HCV globally, and about 30% of infected people will be spontaneously clear, while the others will develop chronic infection, and further progress to cirrhosis and hepatocellular carcinoma (HCC) [1]. In China, the * Correspondence: [email protected] † Equal contributors 4 Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Full list of author information is available at the end of the article
average prevalence of HCV infection is about 3.2%, a total of about 29 million hepatitis C virus carriers [1]. The pathogenesis of HCV infection and chronicity are elusive, but biological characteristics of HCV, host immunity, genetic background and environmental behavior factors are deemed to be interactively involved with the complex pathogenesis [2–4]. The innate and adaptive immune response after the infection of HCV, which varies across individuals, affect the susceptibility and chronicity to HCV infection [5, 6]. The human leukocyte antigen (HLA) system, as the major hi
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