Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowle
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Jamie C. DeWitt Editor
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
Molecular and Integrative Toxicology Series editor Rodney R. Dietert Cornell University College of Veterinary Medicine, Ithaca, New York, USA
More information about this series at http://www.springer.com/series/8792
Jamie C. DeWitt Editor
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
Editor Jamie C. DeWitt Department of Pharmacology and Toxicology Brody School of Medicine, East Carolina University Greenville, NC, USA
ISSN 2168-4219 ISSN 2168-4235 (electronic) Molecular and Integrative Toxicology ISBN 978-3-319-15517-3 ISBN 978-3-319-15518-0 (eBook) DOI 10.1007/978-3-319-15518-0 Library of Congress Control Number: 2015934825 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www. springer.com)
Preface
This book will be of interest to toxicologists, environmental chemists, risk assessors, and others with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances (PFASs). Most of the chapters are written for those with a background in toxicology or chemistry, but background information and references to review articles are included to provide a starting point for those seeking additional information. PFASs are commonly used in myriad industrial and commercial applications. PFASs have provided industries and the general public with products of convenience and safety, including oil- and water-repellent textiles and papers, coatings, and fire-retardants. However, the unintended presence of PFAS in environmental media, including biota, may have adverse effects on the health of exposed organisms. Reports of cancers of the liver, pancreas, and testes in rodents exposed to PFA
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