Traditional uses, phytochemistry, and ethnopharmacology of Colebrookea oppositifolia Smith: a mini-review
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REVIEW
Traditional uses, phytochemistry, and ethnopharmacology of Colebrookea oppositifolia Smith: a mini‑review Gollapalle L. Viswanatha1 · H. Shylaja2 · H. Yogish Kumar3 · M. V. Venkataranganna4 · N. B. L. Prasad5 Received: 13 May 2020 / Accepted: 16 September 2020 © Institute of Korean Medicine, Kyung Hee University 2020
Abstract This review was focused to collect and exemplify the data on traditional uses, phytochemistry, and pharmacological outline of C. oppositifolia, and thereby recognize the current obscurities and highlight the scope and opportunities for future research on the plant. A thorough literature search was performed on C. oppositifolia in the online databases such as Scopus, PubMed/Medline, Science direct, Scifinder, EMBASE, Web of Science, Google scholar, and Elsevier. C. oppositifolia belongs to family Lamiaceae, was widely used in the traditional system of medicine for treating various human ailments. Further, phytochemicals such as acteoside, chrysin, negletein, ladanein, betulonic acid, apigenin, caffeic acid, quercetin, anisofolin A, apigetrin, forsythoside A, β-sitosterol, ferulic acid, and its derivatives were isolated from various parts of C. oppositifolia. Additionally, the plant has been scientifically validated to possess antifertility, anti-ulcer, hepatoprotective, antimicrobial, anti-oxidant, cardioprotective, anti-inflammatory, wound healing, anti-convulsant, and antihypertensive activities in various experimental models. With the available literature we can conclude that despite of enormous traditional uses, the C. oppositifolia has not been explored for its beneficial effects on cataract, rheumatism, joint pain, bleeding disorders, and dysentery. Also, there is a need for clinical studies to explore the efficacy, safety, and toxicity in humans.
* Gollapalle L. Viswanatha [email protected] 1
Independent Researcher, No. 387/511/A, Megalabeedi, Kengeri, Bangalore, Karnataka 560060, India
2
Independent Researcher, Kengeri, Bangalore 560060, India
3
Department of Pharmaceutical Chemistry, JSS College of Pharmacy (Mysore), JSS Academy of Higher Education and Research (JSS AHER), Mysore 570015, India
4
Connexios Life Sciences Pvt Ltd., JP Nagar, Bangalore 560078, India
5
Oil Technology and Pharmaceutical Research Institute (OT & PRI), JNT University Anantapur, Ananthapuramu 515002, India
13
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Graphic abstract
Keywords C. oppositifolia · Lamiaceae · Traditional uses · Phytochemistry · Pharmacology · Ethnopharmacology
Introduction The plant-based medicines are being used in the treatment of many human diseases from the early days of evolution. In these lines, indisputably the great civilization of the ancient Indians, Chinese and North Africans have provided written evidence of man’s inventiveness in employing plants for the treatment of diverse human illnesses (Kritikar and Basu 1987; Pan et al. 2014). Further, the importance of health and its monitoring through varied cultural, social, familial and ritual prac
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