Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
In recent years, great progress has been made in the identification of the molecular players involved in the epigenetic control of gene expression during development. The work of many laboratories has established that regulating the interplay of transcrip
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Constanze Bonifer Peter N. Cockerill Editors
Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
Epigenetics and Human Health
Series Editors Prof. Dr. Robert Feil Universität Tübingen Interfakultäres Inst. Biochemie (IFIB) Tübingen Germany PD Dr. Mario Noyer-Weidner Institut für Biologie Freie Universität Berlin Berlin Germany Prof. Dr. Jörn Walter Universität des Saarlandes PR 8.2 Genetik Saarbrücken Germany
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Constanze Bonifer • Peter N. Cockerill Editors
Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
Editors Constanze Bonifer Peter N. Cockerill University of Birmingham Medical and Dental Sciences Institute of Biomedical Research Birmingham United Kingdom
ISSN 2191-2262 ISSN 2191-2270 (electronic) ISBN 978-3-642-45197-3 ISBN 978-3-642-45198-0 (eBook) DOI 10.1007/978-3-642-45198-0 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2014933585 © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
During vertebrate hematopoiesis many specialized cells types are formed with vastly different functions, such as B
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