Triamcinolone
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Maculopathy (crystalline retinopathy): 16 case reports In a retrospective, interventional, noncomparative, singlecenter chart review consisting of patients who were diagnosed with retinal crystals from September 2006 to July 2010, 16 patients (nine women and seven men) aged 51-95 years were described who developed maculopathy (crystalline retinopathy) following off-label treatment with triamcinolone for branch retinal vein occlusion (BRVO), choroidal neovascularisation (CNV), central retinal vein occlusion (CRVO), diabetic macular oedema (DME) or pseudophakic macular oedema (PPME). The patients had BRVO (n=4), DME (n=9), PPME (n=1), CNV (n=1) and CRVO (n=1). Therefore, they received offlabel treatment with intravitreal injection of triamcinolone [triamcinolone acetonide; Kenalog]. The injection was performed using standard procedure with placement of a sterile lid speculum, povidone iodine preparation, followed by intravitreal administration of triamcinolone [dosages not stated]. Subsequently, all patients developed retinal crystals [time to reactions onsets not stated]. Optical coherence tomography revealed that the crystals were located in preretinal region. Both, fluorescein angiography and indocyanine green angiography demonstrated that the crystals were angiographically silent. The patients were diagnosed with maculopathy (crystalline retinopathy) characterized by clusters of white-yellow, preretinal, refractile crystals. The maculopathy (crystalline retinopathy) was considered to have developed secondary to triamcinolone therapy. Patients were followed-up for 1.1-9.2 years [outcomes not stated]. Author comment: "The off-label use of intravitreal [triamcinolone] is discussed in this manuscript." "A retrospective chart review was performed of patients who had evidence of retinal crystals, not attributable to another retinal or systemic cause, at least one year after the intravitreal injection of [triamcinolone]". Fine HF, et al. CLINICAL FINDINGS IN TRIAMCINOLONE-ASSOCIATED MACULOPATHY. Retina 39: 761-765, No. 4, Apr 2019. Available from: URL: 803436876 http://doi.org/10.1097/IAE.0000000000002007 - USA
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Reactions 30 Nov 2019 No. 1781
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