Urinary MMP-9/NGAL complex in children with acute cystitis
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ORIGINAL ARTICLE
Urinary MMP-9/NGAL complex in children with acute cystitis Sami Hatipoglu & Esra Sevketoglu & Asuman Gedikbasi & Alev Yilmaz & Aysel Kiyak & Mehmet Mulazimoglu & Gonul Aydogan & Tevfik Ozpacaci
Received: 25 December 2010 / Revised: 28 February 2011 / Accepted: 28 February 2011 / Published online: 10 May 2011 # IPNA 2011
Abstract The matrix metalloproteinase-9 (MMP-9) and neutrophil gelatinase associated lipocalin (NGAL) are shown to increase in an inflammatory situation. Based on our previous reports that NGAL can be detected in the urine of children with urinary tract infection (UTI), we also asked whether MMP-9/NGAL complex could be detected in the urine of children with UTI. This multicenter, prospective study was conducted between October 2009 and October 2010. Seventy-one patients with symptomatic culture proven UTI, 37 asymptomatic children with contaminated urine and 37 healthy children were recruited. Mean uMMP9/NGAL/Cr levels were significantly higher in the UTI group than in the control group (p
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