Urine Promising Biomarker Source for Early Disease Detection
This book demonstrates the potential of urine as a biomarker resource for early disease detection, covering the related theory, strategies, tools and findings. Biomarkers are measurable changes associated with diseases. Blood, as a critical part of its in
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Urine
Promising Biomarker Source for Early Disease Detection
Urine
Youhe Gao Editor
Urine Promising Biomarker Source for Early Disease Detection
Editor Youhe Gao College of Life Sciences Beijing Normal University Beijing, Beijing, China
ISBN 978-981-13-9108-8 ISBN 978-981-13-9109-5 (eBook) https://doi.org/10.1007/978-981-13-9109-5 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
Part I Theory, Strategy and Tools 1 Urine Is Not a Human Waste but a Medical Treasure.......................... 3 Youhe Gao 2 Human Urine Proteome: A Powerful Source for Clinical Research............................................................................... 9 Xiaolian Xiao, Lili Zou, and Wei Sun 3 Comparison of Urinary Proteomes Among Three Animal Models......................................................................................... 25 Na Ni and Jianqiang Wu 4 Urimem, a Membrane that Stores Urinary Components for Large-Scale Biomarker Study.......................................................... 33 Lulu Jia, Fanshuang Zhang, and Weiwei Qin 5 Posttranslation Modifications of Human Urine.................................... 41 Weiwei Qin and Mingshan Wang 6 Application of Peptide Level and Posttranslational Modifications to Integrative Analyses in Proteomics............................ 49 Yongtao Liu and Jianrui Yin 7 Urinary Protein Biomarker Database 2.0: A Literature-Curated Database for Protein Biomarkers in Urine............................................ 65 Chen Shao Part II Urinary Biomarkers of Diseases 8 Urine Glucose Levels Are Disordered Before Blood Glucose Level Increase Was Observed in
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