Use of machine perfusion in livers showing steatosis prior to transplantation: a systematic review
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REVIEW ARTICLE
Use of machine perfusion in livers showing steatosis prior to transplantation: a systematic review Quirino Lai1 · Franco Ruberto2 · Timothy M. Pawlik3 · Francesco Pugliese2 · Massimo Rossi1 Received: 1 November 2019 / Accepted: 9 May 2020 © Italian Society of Surgery (SIC) 2020
Abstract Background The role of machine perfusion (MP) in the evaluation of liver grafts with macrovesicular steatosis (MaS) remains ill-defined as only a limited number of studies has been reported. The objective of the current study was to provide a systematic review to evaluate the role of MP in the setting of MaS livers. Methods A systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed. Eligible articles published up to April 2019 were included using the MEDLINE, Scopus, and Google Scholar databases. Results Among the 422 articles screened, only 16 papers met the inclusion criteria. A total of 54 cases of MP use before liver transplantation were included. Sixteen (29.6%) grafts were from donors after circulatory death. In 22 (40.7%) cases, hypothermic machine perfusion was performed. Normothermic machine perfusion was done in the remaining 32 (59.3%) cases. According to the histological results of the donor core biopsy, a MaS value
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