Value of chest computed tomography scan in diagnosis of COVID-19; a systematic review and meta-analysis
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META-ANALYSIS
Value of chest computed tomography scan in diagnosis of COVID‑19; a systematic review and meta‑analysis Hasti Hossein1 · Kosar Mohamed Ali2 · Mostafa Hosseini3 · Arash Sarveazad4,5 · Saeed Safari6,7 · Mahmoud Yousefifard1 Received: 7 August 2020 / Accepted: 6 September 2020 © Italian Association of Nuclear Medicine and Molecular Imaging 2020
Abstract Purpose Real-time polymerase chain reaction (RT-PCR) and chest computed tomography (CT) scan are main diagnostic modalities of coronavirus disease 2019 (COVID-19). However, there is still no consensus on which of these methods is superior to the other. Therefore, the present meta-analysis was designed to answer to the question whether CT scan can be used in diagnosis of COVID-19 or not. Methods Searches were performed in Medline, Embase, Scopus, and Web of Science databases until the end of April 2020. Two researchers gathered the data of diagnostic accuracy studies that had attempted to evaluate sensitivity and specificity of CT scan in diagnosis of COVID-19. Results Data of 9 studies were included. Area under the curve of ground glass opacity (GGO), consolidation, pleural effusion, other CT features, and simultaneous observation of GGO with other CT features was 0.64 (95% CI 0.60–0.69), 0.30 (95% CI 0.26–0.34), 0.60 (95% CI 0.56–0.64), 0.61 (95% CI 0.56–0.65), and 0.90 (95% CI 0.87–0.92), respectively. Sensitivity and specificity of simultaneous observation of GGO with other CT scan features was higher than all of the other signs. Sensitivity, specificity, and diagnostic odds ratio of this sign was calculated to be 0.90, 0.89, and 20, respectively. Conclusion Simultaneous observation of GGO and other features of viral pneumonia in CT scan had optimum performance in detection of COVID-19. However, it is suggested to make the final diagnosis based on both CT scan and RT-PCR, as none of the two diagnostic modalities are reliable alone. Keywords COVID-19 · Severe acute respiratory syndrome coronavirus 2 · Tomography X-ray computed · Polymerase chain reaction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40336-020-00387-9) contains supplementary material, which is available to authorized users. * Saeed Safari [email protected]
2
College of Medicine, University of Sulaimani, Sulaimani, Iraq
* Mahmoud Yousefifard [email protected]
3
Hasti Hossein [email protected]
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4
Kosar Mohamed Ali [email protected]
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
5
Mostafa Hosseini [email protected]
Nursing Care Research Center, Iran University of Medical Sciences, Tehran, Iran
6
Arash Sarveazad [email protected]
Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7
Department of Emergency Medicine, Shohadye Tajrish Hospital, Shahid Beheshti University of Me
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