Comparative study of lung ultrasound and chest computed tomography scan in the assessment of severity of confirmed COVID
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ORIGINAL
Comparative study of lung ultrasound and chest computed tomography scan in the assessment of severity of confirmed COVID‑19 pneumonia Laurent Zieleskiewicz1,2* , Thibaut Markarian3, Alexandre Lopez1, Chloé Taguet3, Neyla Mohammedi1, Mohamed Boucekine4, Karine Baumstarck4, Guillaume Besch5, Gautier Mathon6, Gary Duclos1, Lionel Bouvet7,8,9, Pierre Michelet3, Bernard Allaouchiche6,8,9, Kathia Chaumoître10, Mathieu Di Bisceglie10 and Marc Leone1 on behalf of the AZUREA Network © 2020 Springer-Verlag GmbH Germany, part of Springer Nature
Abstract Purpose: The relationship between lung ultrasound (LUS) and chest computed tomography (CT) scans in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia is not clearly defined. The primary objective of our study was to assess the performance of LUS in determining severity of SARS-CoV-2 pneumonia compared with chest CT scan. Secondary objectives were to test the association between LUS score and location of the patient, use of mechanical ventilation, and the pulse oximetry (SpO2)/fractional inspired oxygen ( FiO2) ratio. Methods: A multicentre observational study was performed between 15 March and 20 April 2020. Patients in the Emergency Department (ED) or Intensive Care Unit (ICU) with acute dyspnoea who were PCR positive for SARS-CoV-2, and who had LUS and chest CT performed within a 24-h period, were included. Results: One hundred patients were included. LUS score was significantly associated with pneumonia severity assessed by chest CT and clinical features. The AUC of the ROC curve of the relationship of LUS versus chest CT for the assessment of severe SARS-CoV-2 pneumonia was 0.78 (CI 95% 0.68–0.87; p
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