Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention
Vegetables, Whole Grains and their Derivatives in Cancer Prevention looks in detail at the evidence regarding the effects and mechanisms of action of potentially cancer-preventive components and their sources from plant kingdom. The book covers current kn
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Series Editor Adriana Albini Head Oncology Research, IRCCS MultiMedica, Via Fantoli 15/16, 20138 Milano, Italy and MultiMedica Castellanza 21053 Castellanza (VA), Italy Tel. +39-02-55406532 Fax +39-02-55406503 [email protected]
For further volumes: http://www.springer.com/series/8049
Marja Mutanen · Anne-Maria Pajari Editors
Vegetables, Whole Grains, and Their Derivatives in Cancer Prevention
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Editors Marja Mutanen Department of Food and Environmental Sciences University of Helsinki Helsinki 00014, Finland [email protected]
Anne-Maria Pajari Department of Food and Environmental Sciences University of Helsinki Helsinki 00014, Finland [email protected]
ISBN 978-90-481-9799-6 e-ISBN 978-90-481-9800-9 DOI 10.1007/978-90-481-9800-9 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010936635 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
This book aims to update our knowledge and increase our understanding on the field of vegetables and whole grains in cancer prevention. There is a long list of bioactive compounds available in vegetable kingdom such as vitamins, minerals, carotenoids, phytosterols, polyphenols etc., which have been intensely studied, often as pure compounds, by several research groups in the diet and cancer field. This book focuses not only on single compounds but aims to widen the view by including data on whole vegetables and grains, their extracts and some of their specific components. Although epidemiological data provide a strong basis for evaluating associations between cancer and environmental factors including diet, making definitive conclusions on the role of diet in cancer prevention would require such inclusive human interventions, which are not possible to conduct. In addition, diet and cancer are two of the most difficult subjects for epidemiological studies to address due to the complex nature of eating patterns and the length of the carcinogenic process. Animal experiments and in vitro cell culture studies form the basis for our understanding in this research field today. Both of these approaches have their limitations, but three main conclusions can be drawn from the results obtained so far; foods contain several components with potential chemopreventive activity; a single component may lose its chemopreventive efficacy when isolated from the food matrix; isolated and concentrated components as supplements may actually induce tumor development. When considering the rate and amount of accumulating new scient
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