Venous obstruction of thyroid malignancy origin: the Antoine Lacassagne Institute experience
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Venous obstruction of thyroid malignancy origin: the Antoine Lacassagne Institute experience Pierre-Yves René Marcy*1, Juliet Thariat2, Alex Bozec3, Gilles Poissonnet3, Danielle Benisvy4 and Olivier Dassonville3 Address: 1Head § Neck Oncology Imaging Department, Antoine Lacassagne Cancer Research Institute, 33 Avenue Valombrose, 06189, Nice, cedex1, France, 2Radiation Therapy Department, Antoine Lacassagne Cancer Research Institute, 33 Avenue Valombrose, 06189, Nice, cedex1, France, 3Head § Neck Oncology Surgery Department, Antoine Lacassagne Cancer Research Institute, 33 Avenue Valombrose, 06189, Nice, cedex1, France and 4Nuclear Medicine Department, Antoine Lacassagne Cancer Research Institute, 33 Avenue Valombrose, 06189, Nice, cedex1, France Email: Pierre-Yves René Marcy* - [email protected]; Juliet Thariat - [email protected]; Alex Bozec - [email protected]; Gilles Poissonnet - [email protected]; Danielle Benisvy - [email protected]; Olivier Dassonville - [email protected] * Corresponding author
Published: 17 April 2009 World Journal of Surgical Oncology 2009, 7:40
doi:10.1186/1477-7819-7-40
Received: 17 February 2009 Accepted: 17 April 2009
This article is available from: http://www.wjso.com/content/7/1/40 © 2009 Marcy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background and aims: To show the benefits of Ultrasonography in the diagnosis of great vein involvement in the neck and mediastinum in thyroid malignancies (primary or secondary) in our experience and to report patient outcomes. Methods: Clinical data were collected from the thyroid unit database of the Antoine Lacassagne Institute. Results: Of 1171 patients with thyroid cancer treated at our institution over the last 18 years, we retrospectively identified nine patients (0.8%), three women and six men, aged 34–81 years (median age: 70 years) presenting with malignant thyroid tumor of median diameter 45 mm (range: 23–87) having venous obstruction of thyroid malignancy origin. Two patients underwent multimodal therapy. All other patients underwent external beam radiation therapy alone ± chemotherapy or palliative care. Ultrasound (US) provided particularly useful information on venous involvement characteristics. Median survival was 7 months and median progression-free survival was 6 months. Survival in our series was worse than that of previously reported series despite diagnosis of vein involvement at an early stage in 2/3 cases using US. Conclusion: Despite small numbers of patients, it seems that aggressive treatment modalities including surgery are required to improve survival. In our experience, US was a useful non-invasive method to describe tumor extensions to great
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