Voriconazole
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Voriconazole Photosensitivity and photoaging reaction in a child: case report A 10-year-old boy developed photosensitivity and photoaging reaction during treatment with oral voriconazole. The boy, who had X-linked chronic granulomatous disease and had been receiving prophylactic voriconazole for the last 3 years, presented with a 3-week history of a photodistributed, pruritic rash over his arms, lower legs and face. Nine weeks prior to presentation, his voriconazole dosage had been increased from 200 mg/day to 400 mg/day because of a fever of unknown origin, which had resolved after dosage increase. He also reported increased sun exposure. He had diffuse erythema with multiple, scattered lentigines on his face and neck, and sharply demarcated, scaly, pink plaques with multiple, scattered lentigines on his arms and legs, which were photodistributed. He was diagnosed with voriconazoleinduced photosensitivity and photoaging reaction. The boy received broad-spectrum sunscreen and topical corticosteroids and his condition significantly improved within 2 weeks. Voriconazole was replaced by itraconazole by his immunologist. Frisch S, et al. X-linked chronic granulomatous disease with voriconazole-induced photosensitivity/ photoaging reaction. Journal of Drugs in Dermatology 9: 562-4, 803027866 No. 5, May 2010 - USA
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Reactions 24 Jul 2010 No. 1311
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