YAP/TAZ affects the development of pulmonary fibrosis by regulating multiple signaling pathways
- PDF / 1,205,587 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 91 Downloads / 151 Views
YAP/TAZ affects the development of pulmonary fibrosis by regulating multiple signaling pathways Ting Zhu1 · Zhifeng Ma1 · Haiyong Wang1 · Xiaoxiao Jia2 · Yuanlin Wu1 · Linhai Fu1 · Zhupeng Li1 · Chu Zhang1 · Guangmao Yu1 Received: 21 April 2020 / Accepted: 31 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract YAP and TAZ are important co-activators of various biological processes in human body. YAP/TAZ plays a vital role in the development of pulmonary fibrosis. Dysregulation of the YAP/TAZ signaling pathway is one of the most important causes of pulmonary fibrosis. Therefore, considering its crucial role, summary of the signal mechanism of YAP/TAZ is of certain guiding significance for the research of YAP/TAZ as a therapeutic target. The present review provided a detailed introduction to various YAP/TAZ-related signaling pathways and clarified the specific role of YAP/TAZ in these pathways. In the meantime, we summarized and evaluated possible applications of YAP/TAZ in the treatment of pulmonary fibrosis. Overall, our study is of guiding significance for future research on the functional mechanism of YAP/TAZ underlying lung diseases as well as for identification of novel therapeutic targets specific to pulmonary fibrosis. Keywords Pulmonary fibrosis · YAP/TAZ · Signaling pathway · Clinical treatment
Introduction Pulmonary fibrosis (PF), also known as diffuse interstitial pulmonary fibrosis, is a progressive, irreversible and fatal lung disease that is caused by multiple reasons [1]. PF is a serious threat to human health worldwide and the incidence rate has been increasing in recent years [2, 3]. PF has become a global disease with significantly increased incidence rate and can be divided into secondary pulmonary fibrosis (SPF) with certain etiology and idiopathic pulmonary fibrosis (IPF) of unknown
origin. The main causes responsible for SPF are rheumatism, pulmonary tuberculosis, or other disease, while for IPF with unknown origin, factors such as genetics, immunity, environment, and age are regarded to make sense. In clinical diagnosis, patients with PF generally suffer from IPF instead of SPF. IPF, a fetal disease [4] with chronic, progressive, and irreversible characteristics [5] is an adult form of diffuse pulmonary fibrosis with a median survival of only 2–3 years after diagnosis [6]. Some studies suggested that patients with IPF have quite poor prognosis and the survival is worse than
* Chu Zhang [email protected]
Linhai Fu [email protected]
* Guangmao Yu [email protected]
Zhupeng Li [email protected]
Ting Zhu [email protected]
1
Department of Thoracic Surgery, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568 Zhongxing North Road, Yuecheng District, Shaoxing 312000, China
2
Department of Pathology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing 312000, China
Zhifeng Ma [email protected] Haiyong Wang [email protected] Xiaoxiao Ji
Data Loading...
