A new disposable electrochemical sensor on medical adhesive tape
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ORIGINAL PAPER
A new disposable electrochemical sensor on medical adhesive tape Gabriela Carolina Mauruto de Oliveira 1 & Jéssica Rocha Camargo 1 & Nirton Cristi Silva Vieira 2 & Bruno Campos Janegitz 1 Received: 20 May 2020 / Revised: 14 June 2020 / Accepted: 16 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract In this work, the use of medical adhesive tape—as a substrate to develop novel sensor architecture for the detection of hemoglobin (HB) has been investigated. The electrodes were fabricated based on the screen-printing method. The proposed electrode was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and cyclic voltammetry. The medical adhesive electrode showed excellent electrochemical behavior for dopamine, which was used for characterization and proof of concept. Also, the electrode was applied for HB electrochemical detection in the range of 1.0 to 10 mg mL−1, with a detection limit of 0.7 mg mL−1 by using differential pulse voltammetry. This sensor has shown resistance to mechanical stress, even when deformed based on its wearable functions, which is an exciting alternative for the development of low-cost electrochemical devices. Keywords Flexible sensor . Screen-printed electrode . Graphite-ink . Hemoglobin
Introduction Personalized medicine is looking for technologies capable of monitoring treatments and progression of diseases in real time, decreasing the dependence of hospital structures [1]. Electrochemical sensors move in this direction because they are compact analytical devices that can be utilized for the detection of various analytes, including disease biomarkers. Besides presenting high performance (good sensitivity, reproducibility, fast and reliable responses), electrochemical sensors are still portable and can be produced in large scale and at low cost [2, 3]. In particular, wearable electrochemical sensors represent the latest advancement in analytical device research. They attract the attention of the scientific community as well as the industry due to their potential to provide real-time, Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10008-020-04732-w) contains supplementary material, which is available to authorized users. * Bruno Campos Janegitz [email protected] 1
Department of Nature Sciences, Mathematics and Education, Federal University of São Carlos, Araras, SP 13600-970, Brazil
2
Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, SP 12231-280, Brazil
continuous, and minimally or non-invasive information about diseases aiming predictive analysis and treatment [1, 4]. A suitable contact between the sensor and the skin could be essential to ensure the efficient functioning of the medical devices. This fact ensures that the printed electrodes do not have cracks or failures under mechanical stress, ensuring good detection reproducibility. Increasing the range of detectable analytes is another great challenge for electroche
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