Advances in Biology and Treatment of Glioblastoma
This volume covers the most important areas of glioblastoma – surgical resection, molecular pathology, targeted therapies, cancer stem cells, the role of DNA methylation, targeted sequencing for personalized therapy, animal models and advances in pediatri
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Kumaravel Somasundaram Editor
Advances in Biology and Treatment of Glioblastoma
Current Cancer Research
Series Editor Wafik El-Deiry
More information about this series at http://www.springer.com/series/7892
Kumaravel Somasundaram Editor
Advances in Biology and Treatment of Glioblastoma
Editor Kumaravel Somasundaram Department of Microbiology and Cell Biology Indian Institute of Science Bangalore, Karnataka, India
ISSN 2199-2584 ISSN 2199-2592 (electronic) Current Cancer Research ISBN 978-3-319-56819-5 ISBN 978-3-319-56820-1 (eBook) DOI 10.1007/978-3-319-56820-1 Library of Congress Control Number: 2017943324 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Glioblastoma (GBM), the grade IV astrocytoma, is the most common primary adult brain tumor. GBM is a fast-growing and most aggressive type of central nervous system tumor. During the last decade, the scientific community is witnessing an incredible amount of progress and successes in cancer research including glioblastoma biology, especially with the use of various high- throughput studies like genomics, proteomics, and next-generation sequencing. While the median survival remains low despite advances on many aspects, we have begun to understand this extremely complex disease primarily because of the coordinated effort between surgeons, pathologists, oncologists, radiologists, and basic research scientists. Many gene signatures for risk stratification and targets for developing novel therapies have been identified. In this aspect, the efforts made by The Cancer Genome Atlas, USA, are highly commendable. Unlike many books,
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