Advances on Modeling in Tissue Engineering

This book presents a collection of chapters describing the state of the art on computational modelling and fabrication in tissue engineering. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of ma

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Computational Methods in Applied Sciences Volume 20

Series Editor E. Oñate International Center for Numerical Methods in Engineering (CIMNE) Technical University of Catalonia (UPC) Edificio C-1, Campus Norte UPC Gran Capitán, s/n 08034 Barcelona, Spain [email protected] www.cimne.com

For other titles published in this series, go to www.springer.com/series/6899

Paulo R. Fernandes • Paulo Jorge Bártolo Editors

Advances on Modeling in Tissue Engineering

Editors Paulo R. Fernandes Instituto Superior Técnico Technical University of Lisbon IDMEC – Instituto de Engenharia Mecânica Av. Rovisco Pais 1 1049-001 Lisboa Portugal [email protected]

Paulo Jorge Bártolo Polytechnic Institute of Leiria Centre for Rapid and Sustainable Product Leiria Portugal [email protected]

ISSN 1871-3033 ISBN 978-94-007-1253-9 e-ISBN 978-94-007-1254-6 DOI 10.1007/978-94-007-1254-6 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011926999 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Cover design: SPi Publisher Services Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Contents

Preface Cell Mechanics: The Role of Simulation Christopher R. Jacobs and Daniel J. Kelly Multiscale Modelling of Bone Tissue – Remodelling and Application to Scaffold Design Helder C. Rodrigues, Pedro G. Coelho, Paulo R. Fernandes Nonlinear Elastic Scaffold Design, Modeling and Fabrication for Soft Tissue Engineering Scott J. Hollister, Claire G. Jeong, J. Jakob Schwiedrzik, Anna G. Mitsak, Heesuk Kang, Francesco Migneco Computational Techniques for Selection of Biomaterial Scaffolds for Tissue Engineering S. Checa, C. Sandino, D.P. Byrne, D.J. Kelly, D. Lacroix and P.J. Prendergast

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15

35

55

Modelling Bone Tissue Engineering. Towards an understanding of the role of scaffold design parameters José A. Sanz-Herrera, Manuel Doblaré and José M. García-Aznar

71

Geometric Modeling and Analysis of Bone Micro–Structures as a Base for Scaffold Design Y. Holdstein, L. Podshivalov, A. Fischer

91

Electrospinning and Tissue Engineering Geoffrey R. Mitchell and Fred Davis

111

Biofabrication Strategies for Tissue Engineering Paulo Jorge Bártolo, Marco Domingos, Tatiana Patrício, Stefania Cometa, Vladimir Mironov

137

Preface

Tissue Engineering is a multidisciplinary field involving scientists from different fields like medicine, chemistry, material science, engineering and biology. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. The scient