An Effective Hybrid Strategy for Conversion of Biomass into Furfurylamine by Tandem Pretreatment and Biotransamination
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An Effective Hybrid Strategy for Conversion of Biomass into Furfurylamine by Tandem Pretreatment and Biotransamination Xiao-Long Liao 1 & Qing Li 1 & Dong Yang 2 Zheng-Bing Jiang 1 & Yu-Cai He 1,2
& Cui-Luan Ma
1
&
Received: 24 December 2019 / Accepted: 23 April 2020/ # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract
In this work, an effective hybrid strategy was developed for tandem conversion of biomass to furfurylamine with tin-based solid acid Sn-Maifanitum stone and recombinant Escherichia coli whole cells harboring ω-transaminase. 90.3 mM furfural was obtained from corncob (75 g/L) at 170 °C for 0.5 h over Sn-Maifanitum stone catalyst (3.5 wt%) in the aqueous media (pH 1.0), which could be further bioconverted into furfurylamine at 74.0% yield (based on biomass-derived furfural) within 20.5 h. Finally, an efficient recycling and reuse of Sn-Maifanitum stone catalyst and immobilized Escherichia coli AT2018 whole-cell biocatalyst was developed for the synthesis of furfurylamine from biomass in the one-pot reaction system. Keywords Furfural . Furfurylamine . Transaminase . Sn-Maifanitum stone . Biotransamination
Introduction With the rapid development of the world economy and the increasing depletion of fossil resources, much attention has been paid to the effective utilization of renewable bioresources [1, 2]. Over the last decades, the production of bio-based chemicals, biofuel molecules, and functional materials from abundant, renewable and carbon-neutral biomass has attracted great interest [3, 4]. Bio-based products are chemicals wholly or partly derived from biomass undergoing physical, chemical, or biological treatment [3–5]. Furfural (FAL) as one key bio-based product, which can be derived from hemicellulose in biomass, has been known
Xiao-Long Liao, Qing Li and Dong Yang contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12010-02003334-6) contains supplementary material, which is available to authorized users.
* Yu-Cai He [email protected]; [email protected] Extended author information available on the last page of the article
Applied Biochemistry and Biotechnology
for decades [5, 6]. It has been widely used for producing biofuels, rubbers, lubricants, oil refining, resins, agrochemicals, and pharmaceuticals [7, 8]. Recently, heterogeneous solid acid catalysts have gained a considerable attention for manufacturing FAL due to their good stability and recyclability [9–16]. Solid acid HSC-SO3H catalyst converted corncob to FAL at 21% yield within 0.5 h at 175 °C in γ-valerolactone–water media [17]. Tin-based solid acid using attapulgite as carrier converted corncob-derived xylose (19.8 g/L) to FAL at 60% yield in toluene–water media [18]. As an important FAL derivative, furfurylamine (FLA), a cyclic amine, is a compound used as intermediate for the production of agrichemicals and fibers [1, 16]. It is also used as a water-miscible solvent and as a key intermediate in manufacturing pharm
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