Animal Cell Culture

​Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation

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Mohamed Al-Rubeai Editor

Animal Cell Culture

Cell Engineering Volume 9

Series Editor Professor Mohamed Al-Rubeai School of Chemical and Bioprocess Engineering University College Dublin Dublin, Ireland Editorial Board Dr Hansjorg Hauser Helmholtz Centre for Infection Research Braunschweig , Germany Professor Michael Betenbaugh Johns Hopkins University Baltimore, USA Professor Martin Fussenegger Swiss Federal Institute of Technology Zurich, Switzerland Dr Otto-Wilhelm Merten A.F.M.-Genethon 11 Gene Therapy Program Evry, France Professor Mariam Naciri Department of Biology Faculty of Science University of Mohammed V-Agdal Rabat, Morocco

More information about this series at http://www.springer.com/series/5728

Mohamed Al-Rubeai Editor

Animal Cell Culture

Editor Mohamed Al-Rubeai University College Dublin Dublin Ireland

ISSN 1389-6946 ISBN 978-3-319-10319-8 ISBN 978-3-319-10320-4 (eBook) DOI 10.1007/978-3-319-10320-4 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014956747 © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

Animal cells are the preferred ‘cell factories’ for the production of complex molecules and antibodies for use as prophylactics, therapeutics