Cell Culture in the Neurosciences
A fundamental problem in neuroscience is the elucidation of the cellular and molecular mechanisms underlying the development and function of the nervous system. The complexity of organization, the heteroge neity of cell types and their interactions, and
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CURRENT TOPICS IN NEUROBIOLOGY Series Editor Samuel H. Barondes Professor of Psychiatry School of Medicine University of California, San Diego La Jolla, California
Tissue Culture of the Nervous System Edited by Gordon Sato Neuronal Recognition Edited by Samuel H. Barondes Pep tides in Neurobiology Edited by Harold Gainer Neuronal Development Edited by Nicholas C. Spitzer Neuroimmunology Edited by Jeremy Brockes Cell Culture in the Neurosciences Edited by Jane E. BoHenstein and Gordon Sa to
A continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediatedly upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
Cell Culture in the Neurosciences Edited by
JANE E. BOTTENSTEIN The Mllritle Biolllediwi Itlslilule atld Oeparhllwl of HUlIlall Biological Chelllishy I/lid Get/elics The Utliversily of Texas MediCtlI Brlltlcl! al Galveslon Galvesloll, Texas
and
GORDON SATO
W. Allotl JOIleS Cell Sciwce Cenler, ItiL LIke Placid, New York
Plenum Press • New York and London
Library of Congress Cataloging in Publication Data Main entry under title: Cell culture in the neurosciences. (Current topics in neurobiology) Includes bibliographies and index. 1. Neurons. 2. Cell culture. I. Bottenstein, Jane E. II. Sato, Gordon. III. Series. [DNLM: 1. Cells, Cultured. 2. Electrophysiology. 3. Neurons-cytology. 4. Neurons-physiology. WL 102.5 0924J QP356.C45 1985
ISBN-13: 978-1-4612-9500-6 DOl: 10.1007/978-1-4613-2473-7
599'.0188
85·3435
e-ISBN-13: 978-1-4613-2473-7
©1985 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1985 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013
All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher
Contributors
JEFFERY L. BARKER
Laboratory of Neurophysiology National Institute of Neurological and Communicative Disorders and Stroke National Institutes of Health Bethesda, Maryland
JANE E. BOTTENSTEIN
Marine Biomedical Institute and Department of Human Biological Chemistry and Genetics University of Texas Medical Branch Galveston, Texas
DOUGLAS E. BRENNEMAN
Laboratory of Developmental Neurobiology National Institutes of Health Bethesda, Maryland
MICHEL DARMON
Unite de Genetique Cellulaire Institut Pasteur Paris, France and Departement de Biologie Cellulaire Centre International de Recherches Dermatologiques Sophia Antipolis Valbonne, France v
vi
Contributors
JEAN DE VELLIS
Departments of Anatomy and Psychiatry UCLA School of Medicine and Mental Retardation Research Center Laboratory of Biomedical and Environmental Sciences University of California Los Angeles, California
BERNARD EDDE
Unite de Genetique Cellulaire Institut Pasteur Paris, France and Laboratoire de Biochimie Cellulaire College de France Paris
