Animal Cell Technology: Products from Cells, Cells as Products Proce
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Animal Cell Technology: Products from Cells, Cells as Products Proceedings of the 16th ESACT Meeting April 25–29, 1999, Lugano, Switzerland Edited by
A. Bernard B. Griffiths W. Noé F. Wurm
KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW
eBook ISBN: Print ISBN:
0-306-46875-1 0-792-36075-3
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CONTENTS 16th ESACT Meeting Organising Committee
xxi
ESACT Executive Committee
xxii
Sponsors
xxiii
Companies Participating in the Trade Exhibition
xxiv
LIST OF PARTICIPANTS
xxv
INTRODUCTION Products from Cells - Cellas as Products
lxxi
ACKNOWLEDGEMENTS
lxxiii
CHAPTER I. Improvement and Induction of High Productivity
Recombinant Pharmaceutical Protein Overexpression in an IRF-I Proliferation Controlled Production System Geserick, C.; Schroeder, K.; Bonarius, H.; Kongerslev, L.; Schlenke, P.; Hauser, H.; Mueller, P.P.
3
The Real Meaning of High Expression Grammatikos, S.I.; Bergemann, K.; Werz, W.; Brax, I.; Bux, R.; Eberhardt, P.; Fieder, J.; Noé, W.
11
A Novel Mammalian Gene Regulation System Responsive to Streptogramin Antibiotics Fussenegger, M.; Von Stockar, B.; Fux, C.; Rimann, R.; Morris, R.; Thompson, C.J.; Bailey, J.E.
19
Feedback Control of Redox Potential in Hybridoma Cell Culture Meneses, A.; Gomez, A.; Ramirez, O.T.
23
Genetic manipulation of the Protein Synthetic Capacity of Mammalian Cells Heaton, M.; Birch, J.; Hovey, A.; Kallmeier, R.; Proud, C.; James, D.
31
vi
Retinoic Acid Enhances Monoclonal Antibody Production of Human-Human Hybridoma BD9 Inoue, Y.; Fujisawa, M.; Shoji, M.; Hashizume, S.; Katakura, Y.; Shirahata
35
Extracellular Adenosine 5’ Monophosphate Controls Proliferation and Stimulates Protein Production of rCHO Cells Bonarius, H.P.J.; Hansen, K.; Kongerslev, L. 39 The Mode of Actions of Lysozyme as an Immunoglobulin Production Stimulating Factor (IPSF) Sugahara, T.; Murakami, F.; Sasaki, T.
43
A Dissection of Recombinant Protein Expression in CHO Cells Indicating Protein-Specific, not Cell Specific,
Limitation Altobello, K.; Chung, YH.; Iovino, J.; Luchette, C.; Overton, S.; Cunningham, M.
47
Effect of Bioreactor Process Control Parameters on Apoptosis and Monoclonal Antibody Production During the Protein-Free Fed-Batch Culture of a Murine Myeloma Moran, E.; McGowan, St.; Reynolds, N.; Wilson, C.
51
Adenovirus Vector Production in 293 Fed-Batch Cultures Wong, K.; Guardia, M.J.; Lee, St.; Hu, W.-S.
55
Influence of BCL-2 Over-Expression on NS0 and CHO Culture Viability and Chimeric Antibody Productivity Tey, B.T.; Singh, R.P.; Al-Rubeai, M.
59
A Regulatable Selective System Facilitating Isolation of High Expres
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