Antimicrobial Activity of Polymeric Microfibers Containing Coix Lacryma-Jobi Extract
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DOI 10.1007/s13233-020-8115-z
www.springer.com/13233 pISSN 1598-5032 eISSN 2092-7673
Antimicrobial Activity of Polymeric Microfibers Containing Coix Lacryma-Jobi Extract Gabriela Lauer Breitenbach1 Marina Giombelli Rosenberger2 Andressa Giombelli Rosenberger1 Josiane Caetano1 Michelly Cristina Galdioli Pellá3 Desirée Tamara Scheidt1 Cleide Viviane Buzanello Martins1 Edvani Curti Munizc3,4,5 Douglas Cardoso Dragunski*,1
1 Center of Engineer and Exact Sciences, State University of West Parana, 85903-000 Toledo-PR, Brazil 2 Department of Biosciences, Federal University of Parana, 85950-000 Palotina-PR, Brazil 3 Department of Chemistry, State University of Maringa, 87020-900 Maringa-PR, Brazil 4 Department of Chemistry, Federal University of Piaui, 64049-550 Teresina-PI, Brazil 5 Material Sci. and Eng. Post-graduation Progr., Federal University of Technology, Parana, 87036-370, Londrina-PR, Brazil
Received February 25, 2020 / Revised April 24, 2020 / Accepted April 26, 2020
Abstract: Wound dressings are based on the creation of ideal environments for cell mobility, gas exchanges and to promote tissue healing and regeneration, besides controlling bacterial proliferation. Electrospinning is a simple, cheap and common technique used for such purposes and Ecovio®, a polymeric blend based on biocompatible polymers (poly(butylene adipate-co-terephthalate) (PBAT) and poly(lactic acid) (PLA)), is a good example of polymer with unique properties for wound dressing materials development. To ensure antimicrobial properties, Job’s tears (Coix lacrymajobi) extract was incorporated into the material. The obtained fiber mats were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffractometry (DRX), optical microscopy (OM), and microbiological analysis. The interaction among the compounds of the extract and the polymeric matrix was inferred by the increase in the crystallinity degree and thermal stability of the fibers/extract. Also, a decrease in the diameter, roughness, and fiber homogeneity was observed. It happened due to the presence of extract in the fibers. Microbiological analysis (antimicrobial activity against S. aureus) indicated the effectiveness of the fibers/extract in preventing this bacteria growth, demonstrating the potential of this material for wound dressing purposes. Keywords: Ecovio®, electrospinning, wound dressing, biomaterial.
1. Introduction When used for biomedical purposes, synthetic and natural compounds are called biomaterials. Currently, they represent a significant fraction of the biomedical alternatives for the application in biological environments.1,2 Implantable materials, artificial organs, controlled release devices, and wound dressings are examples of widely used biomaterials.3,4 Nevertheless, considering their application in biological environments, the basing material is also an important factor. A wide range of polymer-based devices is already use
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