Are recent available blended collagen-calcium phosphate better than collagen alone or crystalline calcium phosphate? Rad
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ORIGINAL ARTICLE
Are recent available blended collagen-calcium phosphate better than collagen alone or crystalline calcium phosphate? Radiotextural analysis of a 1-year clinical trial Tomasz Wach 1
&
Marcin Kozakiewicz 1
Received: 22 May 2020 / Accepted: 17 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Objectives The purpose of this study is to compare bone regeneration properties of recently available collagen-calcium phosphate (C-CP) blend as bone substitute (BS) material in oral surgery with calcium phosphate (CP) as well as collagen material (Collagen). Is C-CP better than the classic loose CP, or is it at least equally effective in the jawbone regeneration with the superiority of a coherent consistency? Materials and methods This study included 102 patients during 12-month follow-up. All patients underwent the following surgical procedures: sinus lift (52patients) and tooth extraction (50patients). Patients were divided into 3 groups which are as follows: experimental group with C-CP, CP and pure Collagen as control groups. Texture analysis was performed in intra-oral radiographs. Analyses were performed in the MaZda 4.6 software. Average 2444-pixel ROIs were established in the image of BS materials and normal trabecular bone for texture comparison to evaluate the jawbone regeneration process. Four features were calculated and investigated. Results Texture analyses revealed that all 4 features described the healing process well. Reference textural value of feature SumOfSqrs < 102.37 was soft tissue, DifEntr < 1.1 was not the bone, Entr < 2.62 was not a bone and LngREmph > 1.8 was soft tissue. For 12 months, bone regeneration was proved by 3 of 4 investigated features. Only Entr indicated to CP remnants in the ROI (p < 0.05). Conclusions This study proves that blended collagen-calcium phosphate as a BS material can bring satisfactory and predictable outcomes in jawbone regeneration. Clinical relevance Clinicians can choose a satisfactory and predictable material for bone regeneration treatment. Keywords Osteoconduction . Calcium phosphates . Collagen . Bone regeneration
Introduction Today, various forms of calcium phosphates (CPs) are the most commonly used bone replacement materials due to their ease of application and handling, safety profile, intraoperative cost, time advantages and adaptability to a variety of clinical indications [1–4]. The biologically active glasses or methyl methacrylate polymer, formerly used, are now marginalised. But alpha,
* Tomasz Wach [email protected] 1
Department of Maxillofacial Surgery, Medical University in Lodz, Pl. Hallera 1, 90-647 Łódź, Poland
beta and crystalline calcium phosphates have become widespread in oral surgery. Those used in oral surgery are usually available in granular form that does not allow to shape well biomaterials in the surgical field during the surgery procedure. Developing oral surgery and implantology has led to identification of other needs. It means that surgeons are expecting better and more pr
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